Cytogenetics of Mammalian Embryonic Development
نویسندگان
چکیده
منابع مشابه
Programmed Cell Senescence during Mammalian Embryonic Development
Cellular senescence disables proliferation in damaged cells, and it is relevant for cancer and aging. Here, we show that senescence occurs during mammalian embryonic development at multiple locations, including the mesonephros and the endolymphatic sac of the inner ear, which we have analyzed in detail. Mechanistically, senescence in both structures is strictly dependent on p21, but independent...
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In most species, self-sustained molecular clocks regulate 24-h rhythms of behavior and physiology. In mammals, a circadian pacemaker residing in the hypothalamic suprachiasmatic nucleus (SCN) receives photic signals from the retina and synchronizes subordinate clocks in non-SCN tissues. The emergence of circadian rhythmicity during development has been extensively studied for many years. In mic...
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the DNA double helix, is organized into a complex chromatin structure with the assistance of histone and nonhistone proteins. As such, chromatin is the physiologically relevant form of eukaryotic genomes. While it is largely uncontested that different genetic compositions of individual species underlie their unique physiology and final morphology, chromatin provides an additional layer for dict...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1988
ISSN: 1468-6244
DOI: 10.1136/jmg.25.8.575